Intelligent Dosing System (IDS) tm
The Intelligent Dosing System (IDS™)is a computerized decision support system that calculates the best next dose to titrate a patient on a single drug, or combination of drugs to achieve an optimal response. Utilizing proprietary dose-response technology the IDS draws a correlation between the patient’s previous dose and response, the current dose and response and a desired response to provide the next dose required to achieve the desired surrogate marker. Specifically, the IDS recommends, the next dose necessary to reach a desired effect with an accuracy of 90% to 97%. The IDS has been approved by the FDA’s CDRH as a Class II Medical Device for all drugs as well as to be prescribed for a patient's at home use under a physician's supervision for Insulin.
The IDS is a new method of dose calculation, which predicts the best dose of drug to be administered to an individual patient based on the particular patient’s previous dose and toxicity information. Therefore, this method provides a simple individualized dose calculation system, which depends only on the two pieces of information readily available to the physician, previous dose given and the desired outcome. The IDS incorporates a mathematical formula that relates previous dose, previous response with next dose and next response. The function is a four-parameter nonlinear equation and is designed to alter the degree of responsiveness based on the value of the previous dose. At low doses, relative to the normal dosing range of the drug, the dose/level relationship is relatively linear. However at high doses the dose/level relationship is nonlinear and becomes increasingly more nonlinear with higher doses
The patented mathematical relationship behind the IDS illustrates the dose response curve for a particular drug by using the maximum dose range of a drug with our designer equation. This equation relates the current dose and response of a drug to the next dose and response. Since various factors can influence a subject's response aside from dose alone. The IDS individualizes dosing based on the previous dosing experience and is the first system to draw correlations between dose and biological markers other than level.
The Multi-Agent Dosing System (MAIDS) provides the means to individualize the dosage of two or more drugs based on the measured cumulative change in a marker. The proportion of each drug is multiplied by a mathematically derived value that represents the individual contribution of each drug. From this the intrinsic potency each drug contributes to the overall response in the patient can be calculated. The positive (efficacy) and negative (toxicity) effects of the individual and combined drugs can be identified and illustrated to optimize complex multi-agent treatment interventions.